|
Liver diseases
|
0.300 |
Biomarker
|
group |
CTD_human |
Blood gene expression markers to detect and distinguish target organ toxicity.
|
19784758 |
2010 |
|
Hypertensive disease
|
0.080 |
GeneticVariation
|
group |
BEFREE |
The frequency of single nucleotide polymorphisms in arginase-1 (ARG1 rs2781666) and dimethylarginine dimethylaminohydrolase-1 (DDAH1 rs480414) genes has been found to differ in a cohort of bronchopulmonary dysplasia patients with pulmonary hypertension (cases) and without pulmonary hypertension (controls).
|
30267614 |
2018 |
|
Hypertensive disease
|
0.080 |
Biomarker
|
group |
BEFREE |
The lack of protection in cardiac and aortic tissues may be due to DDAH1 tissue selectivity and/or the extent of hypertension by the used combined model.
|
23110194 |
2012 |
|
Hypertensive disease
|
0.080 |
Biomarker
|
group |
BEFREE |
Regulation of DDAH1 by miR-21 plays a role in the development of hypoxia-induced pulmonary hypertension and may be of broader significance in pulmonary hypertension.
|
24895913 |
2014 |
|
Hypertensive disease
|
0.080 |
Biomarker
|
group |
BEFREE |
Together, our results demonstrated that DDAH1 plays an important role in attenuating monocrotaline-induced lung oxidative stress, pulmonary hypertension and RV hypertrophy in rats.
|
31402164 |
2019 |
|
Hypertensive disease
|
0.080 |
GeneticVariation
|
group |
BEFREE |
Furthermore, the DDAH1 and COL18A1 genes were associated with systolic BP change (P < 1.00 × 10(-6) and P = 4.00 × 10(-6), respectively), while EDNRA was associated with hypertension incidence (P = 2.39 × 10(-4)).
|
25424718 |
2015 |
|
Hypertensive disease
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Our results show that NRP1 is required for full expression of DDAH1 in endothelial cells and that NRP1 contributes to protection from low-dose angiotensin II-induced increases in blood pressure.-Wang, Y., Wang, E., Zhang, Y., Madamsetty, V. S., Ji, B., Radisky, D. C., Grande, J. P., Misra, S., Mukhopadhyay, D. Neuropilin-1 maintains dimethylarginine dimethylaminohydrolase 1 expression in endothelial cells, and contributes to protection from angiotensin II-induced hypertension.
|
30118322 |
2019 |
|
Hypertensive disease
|
0.080 |
GeneticVariation
|
group |
BEFREE |
Our results indicated that the C-allele of rs3087894 in DDAH1 was a risk factor for hypertension in the Kazakh group but a protective factor in the Uygur group.
|
26786611 |
2016 |
|
Hypertensive disease
|
0.080 |
GeneticVariation
|
group |
BEFREE |
In that study a novel functional mutation of DDAH-1 was identified; the mutation carriers had a significantly elevated risk for cardiovascular disease and a tendency to develop hypertension.
|
16444868 |
2005 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
VEGF, HIF-1α and iNOS expression did not differ in DDAH1 mutant-positive tumors compared to control tumors, but was upregulated in wild-type DDAH1 overexpressing tumors.
|
29150732 |
2018 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
However, overexpression of DDAH I had no measurable effect on tumour growth, vessel density, function or maturation.
|
29721731 |
2018 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
DDAH-1 expression was significantly induced in primary HCC tumors compared to non-tumorous background liver.
|
28741166 |
2017 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
These findings suggest that DDAH1 functions as a tumor suppressor in GC and may be exploited as a diagnostic and prognostic biomarker for GC.
|
28580735 |
2017 |
|
Diabetes Mellitus
|
0.030 |
Biomarker
|
group |
BEFREE |
Innovation and Conclusion: Our results provide the first direct evidence that the DDAH1 has a marked effect on kidney fibrosis and oxidative stress induced by aging or diabetes.
|
28594240 |
2017 |
|
Diabetes Mellitus
|
0.030 |
Biomarker
|
group |
BEFREE |
Streptozotocin (STZ) was used to induce diabetes in adult DDAH1 knock-out and wild type mice.Healthy mice served as controls.
|
31818438 |
2019 |
|
Diabetes Mellitus
|
0.030 |
Biomarker
|
group |
BEFREE |
Our data demonstrated that inducible nitric oxide synthase/gamma-Glutamyl-cysteine ligase (iNOS/GGCL) and DDAH dysregulation may play a key role in high glucose mediated oxidative stress, whereas HO-1 inducers such as CAPE or its more potent derivatives may be useful in diabetes and other stress-induced pathological conditions.
|
31108850 |
2019 |
|
Malignant Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Increased DDAH1 expression and NO production have been linked to multiple pathological conditions including cancer.
|
28580735 |
2017 |
|
Malignant Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Increased DDAH1 expression and subsequent increased NO production have been recently linked to cancer.
|
30611984 |
2019 |
|
Cardiovascular Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
This study comprised a genome-wide association analysis of 3 well-characterized population-based cohorts (Framingham Heart Study [FHS; n=2992], Gutenberg Health Study [GHS; n=4354], and Multinational Monitoring of Trends and Determinants in Cardiovascular Disease Study [MONICA]/Cooperative Health Research in the Augsburg Area, Augsburg, Bavaria, Germany [KORA] F3 [n=581]) and identified replicated loci (DDAH1, MED23, Arg1, and AGXT2) associated with the interindividual variability in ADMA, l-arginine, and SDMA.
|
25245031 |
2014 |
|
Cardiovascular Diseases
|
0.020 |
GeneticVariation
|
group |
BEFREE |
In that study a novel functional mutation of DDAH-1 was identified; the mutation carriers had a significantly elevated risk for cardiovascular disease and a tendency to develop hypertension.
|
16444868 |
2005 |
|
Kidney Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
In this review, the recent advances in the regulation and function of DDAH enzymes, their roles in the regulation of NO generation, and their possible contribution to endothelial dysfunction in patients with cardiovascular and kidney diseases are discussed.
|
17933965 |
2007 |
|
Kidney Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
Ddah1(PT-/-) mice were protected from reduced kidney tissue mass, collagen deposition, and profibrotic cytokine expression in two independent renal injury models: folate nephropathy and unilateral ureteric obstruction.
|
25855779 |
2015 |
|
Primary malignant neoplasm
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Increased DDAH1 expression and subsequent increased NO production have been recently linked to cancer.
|
30611984 |
2019 |
|
Primary malignant neoplasm
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Increased DDAH1 expression and NO production have been linked to multiple pathological conditions including cancer.
|
28580735 |
2017 |
|
Chronic Kidney Diseases
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Emerging evidence suggests that plasma ADMA accumulation and DDAH1 activity/expression reduction are linked to chronic kidney disease (CKD) pathology, but the mechanisms remain largely unknown.
|
28594240 |
2017 |